Expression of DGCR8-Dependent MicroRNAs Is Indispensable for Osteoclastic Development and Bone-Resorbing Activity
نویسندگان
چکیده
منابع مشابه
Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells.
OBJECTIVE In aseptic loosening, a heavy macrophage response to biomaterial wear particles is commonly found in arthroplasty tissues. The aim of this study was to discover if these cells contribute to the bone resorption of aseptic loosening by differentiating into osteoclasts. METHODS Macrophages were isolated from the pseudocapsule and pseudomembrane of loose cemented and uncemented hip arth...
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15 صفحه اولDGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs leads to reduced FoxP3 expression in Treg cells in vivo. In vitro culture of purified DGCR8-defici...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2014
ISSN: 0730-2312
DOI: 10.1002/jcb.24759